Universities of Edinburgh, Madrid & Navarra

Dr Leonard J Nelson (Edinburgh)
Dr Francisco Javier Cubero (Madrid)
Professor Matías Ávila (Navarra)

In their work investigating, “A Novel Therapeutic Approach for Cholangiocarcinoma”, the team are aiming to evaluate the efficacy of dual tyrosine inhibition against EGFR (c-ErbB1) and HER2 (c-ErbB2) receptors which play a fundamental role in cholangiocarcinoma initiation and progression.

Update 2020/21:
To see the team’s work published in the journal, Hepatology, November 2020, Dual targeting of G9a and DNMT1 for the treatment of experimental cholangiocarcinoma” go to: https://doi.org/10.1002/hep.31642

For the work published in the journal, Hepatology, April 2020,  “Loss of c‐Jun N‐terminal Kinase 1 and 2 Function in Liver Epithelial Cells Triggers Biliary Hyperproliferation Resembling Cholangiocarcinoma”, go to: https://doi.org/10.1002/hep4.1495

And for the work published in the journal, Gut, August 2021, “Next-generation sequencing of bile cell-free DNA for the early detection of patients with malignant biliary strictures”, go to: http://dx.doi.org/10.1136/gutjnl-2021-325178

Back to: AMMF Grants for Research